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The Manual of Simulation in Healthcare, Second Edition is fully revised and updated. It is divided into three sections, beginning with a description of the logistics of establishing a simulation and skills centre and the inherent problems with funding, equipment, staffing, course development, and promotion. The following section details a broad array of considerations for healthcare-centred simulation within medical education and reviews the steps required to develop courses that comply with 'best practice' in medical education. The final section presents simulation scenarios applied to a range of medical scenarios. New material focussing on patient safety, interprofessional education and critical care medicine represent current practice and a revised glossary of terms, acronyms, and abbreviations encountered in the areas of education, acute care medicine, simulation, and aviation has been included to enable the reader to better understand the language used by simulation experts. The Manual of Simulation in Healthcare, Second Edition provides an in-depth understanding of how medical educators can best incorporate simulation teaching methodologies into their curricula and is an invaluable resource to teachers across all the medical specialties.