7. Shuttling of Acetyl Groups across the Inner Mitochondrial Membrane The acetyl group of acetyl-CoA, produced by the oxidative decarboxylation of pyruvate in the mitochondrion, is transferred to the cytosol by the acetyl group shuttle outlined in Figure 20-10.
(a) Write the overall equation for the transfer of one acetyl group from the mitochondrion to the cytosol.
(b) What is the cost of this process in ATPs per acetyl group?
(c) In Chapter 17 we encountered an acyl group shuttle in the transfer of fatty acyl-CoA from the cytosol to the mitochondrion in preparation for β oxidation (see Fig. 17-6). One result of that shuttle was separation of the mitochondrial and cytosolic pools of CoA. Does the acetyl group shuttle also accomplish this? Explain.