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Animal Science Cell and Molecular Biology

LDL cholesterol question

12. LDL cholesterol (the bad cholesterol binds to the scavenger receptor LDLR. It is then removed from the blood and prevented from causing atherosclerosis via endocytosis of the LDLR and degradation of the LDL in the lysosomes inside the cell. Endocytosis of LDLR is controlled by NXPYmotifs in its cytoplasmic tail. (i) What does the NXPY motif in the LDLR normally bind to that allows the LDLR and its bound LDL to be endocytosed? (ii) What happens to the LDL cholesterol levels in the blood in a person heterozygous for the Y807C mutation in the NXPY motif? (iii) How is this linked to the development of high blood pressure?

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