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(b) Compound 1 is a new lead structure that has been found to enhance the effect of cancer therapeutics. A SAR study was undertaken and a series of new compounds (2-7) were prepared, both the structures and relative biological activity for these compounds is shown below. Interpret these results with respect to SAR and propose a pharmacophore for 1 1000 times less active than 1 same activity as 1 10 times less active than 1 same activity as 1 5 times more active than 1

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