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Question 2: Compartmentalization and vesicular trafficking

Part A

i.               BMPRII is a glycosylated membrane protein. State where in the cell, this protein was glycosylated. (1 mark)

 

ii.             Explain how a newly synthesised polypeptide chain is transferred to the region in the cell where glycosylation occurs and how it moves from there to the plasma membrane. (9 marks)

 

 

Part B

COVID-19 belongs to a broad family of viruses called Coronaviruses, causing severe acute respiratory syndrome (SARS). Recent research illustrated that the SARS-CoV-2 spike protein (ligand) binds to its plasma membrane specific receptor (ACE2) via its Receptor-binding domain.

      i.         Please state two (2) reasons why COVID19 cannot be classified as a cell. (2 marks)

 

    ii.         From your knowledge of vesicular trafficking, name a mechanism by which COVID-19 virus can enter the cell after it binds to the ACE2 receptor on the host’s plasma membrane. (1 mark)

 

   iii.         Explain this mechanism. (7 marks)

 

 

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